Clinical utility and real-world application of molecular genetic sequencing in the management of patients with acute myeloid leukemia and myelodysplastic syndromes

• Published in: Leukemia & lymphoma Vol. 63; no. 3; pp. 684 - 693
• Main Authors: Banaszak, Lauren G., Reinig, Erica, Lasarev, Michael R., Mattison, Ryan J.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 23.02.2022
• Subjects: High-Throughput Nucleotide Sequencing; Humans; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - therapy; Molecular Biology; molecular genetics; Mutation; Myelodysplastic Syndromes - diagnosis; Myelodysplastic Syndromes - genetics; Myelodysplastic Syndromes - therapy; Myeloid leukemias and dysplasias; prognostication; molecular genetics; prognostication; Myeloid leukemias and dysplasias
• ISSN: 1042-8194; 1029-2403
• DOI: 10.1080/10428194.2021.1999435

Recurrently mutated genes in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have proven useful in risk stratification and clinical decision-making. Sequencing technologies that detect these genetic mutations are now widely available, though there is variability in the use of such data among hematologists. Molecular genetic sequencing trends were assessed in 470 patients presenting to a single institution with AML or MDS to determine how molecular data impacts clinical management of patients with myeloid malignancies. Patients with AML were more likely to have molecular genetic sequencing performed compared to patients with MDS, and clinicians were more likely to reference molecular data in decision-making for patients with AML. Furthermore, the presence of molecular data was associated with an increased odd of bone marrow transplantation (BMT). This study demonstrates the real-world application of molecular data in the management of myeloid malignancies and also highlights disparities in the use of such data based on diagnosis.