The effect of angiotensin-converting enzyme polymorphism on hemodynamic response to endotracheal intubation in hypertensive patients
Endotracheal intubation elicits a hemodynamic response associated with increased heart rate and blood pressure that is influenced by the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) genetic polymorphism which may be of importance also for the pressure response to anesthesia. A tota...
Saved in:
Published in | Scandinavian journal of clinical and laboratory investigation Vol. 76; no. 5; pp. 368 - 372 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Taylor & Francis
03.07.2016
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Endotracheal intubation elicits a hemodynamic response associated with increased heart rate and blood pressure that is influenced by the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) genetic polymorphism which may be of importance also for the pressure response to anesthesia. A total of 337 patients underwent abdominal surgery in general anesthesia and 16% were D/D-homozygotes, 45% were I/D heterozygotes and 39% of the patients were I/I homozygotes. Before surgery most patients were in treatment for arterial hypertension. Systolic and diastolic pressure, heart rate and concentrations of catecholamines in blood were determined before and after induction of anesthesia and for up to 10 minutes following endotracheal intubation. Anesthesia decreased blood pressure and for patients presenting ID and DD, blood pressure and heart rate reached similar levels but compared to II-homozygotes, D-carriers demonstrated significantly higher levels for systolic pressure and heart rate before and after intubation (p < 0.05). The blood levels of catercholamines were similar in the three genotype groups. The incidence of ECG-determined myocardial ischemia was higher in D-allele carriers compared to I-allele homozygotes (DD 22%, ID 25% vs. II 5%). In response to anesthesia and intubation and independent of sympathetic nervous activity, D-allele carriers for ACE polymorphism increased blood pressure response and higher risk for development of cardiovascular complications compared to patients homozygous for the I-allele. |
---|---|
AbstractList | Endotracheal intubation elicits a hemodynamic response associated with increased heart rate and blood pressure that is influenced by the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) genetic polymorphism which may be of importance also for the pressure response to anesthesia. A total of 337 patients underwent abdominal surgery in general anesthesia and 16% were D/D-homozygotes, 45% were I/D heterozygotes and 39% of the patients were I/I homozygotes. Before surgery most patients were in treatment for arterial hypertension. Systolic and diastolic pressure, heart rate and concentrations of catecholamines in blood were determined before and after induction of anesthesia and for up to 10 minutes following endotracheal intubation. Anesthesia decreased blood pressure and for patients presenting ID and DD, blood pressure and heart rate reached similar levels but compared to II-homozygotes, D-carriers demonstrated significantly higher levels for systolic pressure and heart rate before and after intubation (p < 0.05). The blood levels of catercholamines were similar in the three genotype groups. The incidence of ECG-determined myocardial ischemia was higher in D-allele carriers compared to I-allele homozygotes (DD 22%, ID 25% vs. II 5%). In response to anesthesia and intubation and independent of sympathetic nervous activity, D-allele carriers for ACE polymorphism increased blood pressure response and higher risk for development of cardiovascular complications compared to patients homozygous for the I-allele. Endotracheal intubation elicits a hemodynamic response associated with increased heart rate and blood pressure that is influenced by the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) genetic polymorphism which may be of importance also for the pressure response to anesthesia. A total of 337 patients underwent abdominal surgery in general anesthesia and 16% were D/D-homozygotes, 45% were I/D heterozygotes and 39% of the patients were I/I homozygotes. Before surgery most patients were in treatment for arterial hypertension. Systolic and diastolic pressure, heart rate and concentrations of catecholamines in blood were determined before and after induction of anesthesia and for up to 10 minutes following endotracheal intubation. Anesthesia decreased blood pressure and for patients presenting ID and DD, blood pressure and heart rate reached similar levels but compared to II-homozygotes, D-carriers demonstrated significantly higher levels for systolic pressure and heart rate before and after intubation (p < 0.05). The blood levels of catercholamines were similar in the three genotype groups. The incidence of ECG-determined myocardial ischemia was higher in D-allele carriers compared to I-allele homozygotes (DD 22%, ID 25% vs. II 5%). In response to anesthesia and intubation and independent of sympathetic nervous activity, D-allele carriers for ACE polymorphism increased blood pressure response and higher risk for development of cardiovascular complications compared to patients homozygous for the I-allele. |
Author | Wang, Zhi-Ping Shao, Mu-Qing Wang, Hao-Xing Wang, Jun Mu, Hui-Jun |
Author_xml | – sequence: 1 givenname: Jun surname: Wang fullname: Wang, Jun email: wangjun19710930@126.com organization: Departments of Anesthesiology – sequence: 2 givenname: Zhi-Ping surname: Wang fullname: Wang, Zhi-Ping organization: Departments of Anesthesiology – sequence: 3 givenname: Hao-Xing surname: Wang fullname: Wang, Hao-Xing organization: Departments of Anesthesiology – sequence: 4 givenname: Mu-Qing surname: Shao fullname: Shao, Mu-Qing organization: Electrocardiogram – sequence: 5 givenname: Hui-Jun surname: Mu fullname: Mu, Hui-Jun organization: Central Laboratory, the Affiliated Wuxi People's Hospital of Nanjing Medical University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27219718$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kc1u3CAUhVGVqpmkfYRWLLvxlAs2tnetov5JkbpJ1wjjS4bKBheYVM66D16smXSZFRfud86ROFfkwgePhLwFtgfWsQ-MCdk0IPacgdwDdII3_Quyg4bxqpWdvCC7jak26JJcpfSLlbvo6lfkkrcc-ha6Hfl7d0CK1qLJNFiq_b0LGX1yvjLBP2DMzt9T9I_rjHQJ0zqHuBxcmmnw9IBzGFevZ2doxLQEn5DmUPAx5KjNAfVEnc_HQWdXeFck61I8t4CH4lee0ef0mry0ekr45nxek59fPt_dfKtuf3z9fvPptjJCylzVre44oGFDKwfWDtZyIXvNATSrZW-F0WUn7SC7Mo-jRGhrIUfeQq0lSHFN3p98lxh-HzFlNbtkcJq0x3BMCjrecKh7Vhe0OaEmhpQiWrVEN-u4KmBqK0A9FaC2AtS5gKJ7d444DjOO_1VPP16AjyfAeRvirP-EOI0q63UK0UbtjUtKPJ_xDxTsmmI |
CitedBy_id | crossref_primary_10_1016_j_clinthera_2020_07_012 |
Cites_doi | 10.1097/00004872-199612000-00003 10.1002/elps.1150080109 10.1113/jphysiol.1969.sp008680 10.1023/A:1007820401377 10.1007/s11906-003-0010-4 10.1139/H07-147 10.1016/j.amjcard.2003.07.043 10.1038/jhh.2008.123 10.1007/s00408-013-9469-1 10.1007/s00228-014-1751-5 10.2165/00003495-200262070-00001 10.1177/1470320310375859 10.4103/0970-9185.76635 10.1161/01.HYP.0000128242.41442.71 10.1097/00004872-199715120-00059 10.1172/JCI114844 10.1161/01.RES.0000223145.74217.e7 10.1161/01.CIR.92.6.1387 10.1097/01213011-200502000-00003 10.1177/1076029608315163 10.1093/bja/59.6.707 10.1016/j.jns.2014.07.023 10.2337/diabetes.51.6.1986 |
ContentType | Journal Article |
Copyright | 2016 Medisinsk Fysiologisk Forenings Forlag (MFFF) 2016 |
Copyright_xml | – notice: 2016 Medisinsk Fysiologisk Forenings Forlag (MFFF) 2016 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1080/00365513.2016.1183259 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1502-7686 |
EndPage | 372 |
ExternalDocumentID | 10_1080_00365513_2016_1183259 27219718 1183259 |
Genre | Original Article Journal Article |
GroupedDBID | --- -~X 00X 03L 0BK 0R~ 123 36B 4.4 53G 5RE AAJNR AALUX AAMIU AAPUL AAPXX AAQRR AAWTL ABBKH ABDBF ABEIZ ABLJU ABLKL ABOCM ABPTK ABUPF ACENM ACFUF ACGEJ ACGFS ACLSK ADCVX ADFCX ADRBQ ADXPE AECIN AENEX AEOZL AEYQI AFKVX AFWLO AGDLA AGFJD AGRBW AGYJP AIJEM AIRBT AJWEG AKBVH ALIIL ALMA_UNASSIGNED_HOLDINGS ALQZU AMDAE BABNJ BLEHA BOHLJ CCCUG COF CS3 DKSSO DU5 EAP EAS EBB EBC EBD EBS EBX EHN EJD EMB EMK EMOBN EPL EPT ESX F5P H13 HZ~ J.N KRBQP KSSTO KWAYT KYCEM L7B LJTGL M4Z O9- P2P Q~Q RNANH RVRKI SV3 TFDNU TFL TFW TUS UEQFS UHWXJ V1S WH7 ZA5 ~1N .55 .GJ 34G 39C 3O- 5VS AALIY AAQQT ABJNI ABLIJ ABWCV ABXYU ABZEW ACIEZ ACKZS ADFOM ADFZZ AEIIZ AFFNX AFLEI AJVHN ALYBC AWYRJ BRMBE CAG CGR CUY CVF CYYVM CZDIS DRXRE DWTOO ECM EIF JENTW M44 NPM NUSFT OVD QQXMO TBQAZ TDBHL TEORI TERGH TUROJ X7M ZGI ZXP AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c366t-47a821ec0b76b07bff2369a211a0469f3cac0b6fb68f3cdd6e17436d2714a6163 |
ISSN | 0036-5513 |
IngestDate | Fri Aug 16 07:09:15 EDT 2024 Fri Aug 23 02:36:56 EDT 2024 Tue Aug 27 13:48:14 EDT 2024 Tue Jun 13 19:24:39 EDT 2023 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 5 |
Keywords | intubation Angiotensin converting enzyme gene hypertension intratracheal complications |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c366t-47a821ec0b76b07bff2369a211a0469f3cac0b6fb68f3cdd6e17436d2714a6163 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 27219718 |
PQID | 1825214904 |
PQPubID | 23479 |
PageCount | 5 |
ParticipantIDs | proquest_miscellaneous_1825214904 informaworld_taylorfrancis_310_1080_00365513_2016_1183259 pubmed_primary_27219718 crossref_primary_10_1080_00365513_2016_1183259 |
PublicationCentury | 2000 |
PublicationDate | 2016-07-03 |
PublicationDateYYYYMMDD | 2016-07-03 |
PublicationDate_xml | – month: 07 year: 2016 text: 2016-07-03 day: 03 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Scandinavian journal of clinical and laboratory investigation |
PublicationTitleAlternate | Scand J Clin Lab Invest |
PublicationYear | 2016 |
Publisher | Taylor & Francis |
Publisher_xml | – name: Taylor & Francis |
References | CIT0010 CIT0012 CIT0014 CIT0013 CIT0016 CIT0015 CIT0018 CIT0017 CIT0019 Erdos EG (CIT0001) 1987; 56 CIT0021 CIT0020 CIT0023 CIT0022 Zaman MM (CIT0011) 2001; 27 CIT0003 CIT0002 CIT0024 CIT0005 CIT0004 Bafna U (CIT0025) 2011; 27 CIT0007 CIT0006 CIT0009 CIT0008 |
References_xml | – ident: CIT0022 doi: 10.1097/00004872-199612000-00003 – ident: CIT0014 doi: 10.1002/elps.1150080109 – ident: CIT0012 doi: 10.1113/jphysiol.1969.sp008680 – ident: CIT0023 doi: 10.1023/A:1007820401377 – ident: CIT0007 doi: 10.1007/s11906-003-0010-4 – ident: CIT0016 doi: 10.1139/H07-147 – ident: CIT0018 doi: 10.1016/j.amjcard.2003.07.043 – ident: CIT0015 doi: 10.1038/jhh.2008.123 – ident: CIT0020 doi: 10.1007/s00408-013-9469-1 – ident: CIT0021 doi: 10.1007/s00228-014-1751-5 – ident: CIT0002 doi: 10.2165/00003495-200262070-00001 – ident: CIT0010 doi: 10.1177/1470320310375859 – volume: 27 start-page: 43 year: 2011 ident: CIT0025 publication-title: J Anaesthesiol Clin Pharmacol doi: 10.4103/0970-9185.76635 contributor: fullname: Bafna U – ident: CIT0006 doi: 10.1161/01.HYP.0000128242.41442.71 – ident: CIT0009 doi: 10.1097/00004872-199715120-00059 – ident: CIT0005 doi: 10.1172/JCI114844 – ident: CIT0019 doi: 10.1161/01.RES.0000223145.74217.e7 – ident: CIT0004 doi: 10.1161/01.CIR.92.6.1387 – ident: CIT0024 doi: 10.1097/01213011-200502000-00003 – ident: CIT0017 doi: 10.1177/1076029608315163 – ident: CIT0013 doi: 10.1093/bja/59.6.707 – volume: 27 start-page: 90 year: 2001 ident: CIT0011 publication-title: Bangladesh Med Res Counc Bull contributor: fullname: Zaman MM – ident: CIT0008 doi: 10.1016/j.jns.2014.07.023 – volume: 56 start-page: 345 year: 1987 ident: CIT0001 publication-title: Lab Invest contributor: fullname: Erdos EG – ident: CIT0003 doi: 10.2337/diabetes.51.6.1986 |
SSID | ssj0003384 |
Score | 2.1413388 |
Snippet | Endotracheal intubation elicits a hemodynamic response associated with increased heart rate and blood pressure that is influenced by the angiotensin-converting... |
SourceID | proquest crossref pubmed informaworld |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 368 |
SubjectTerms | Aged Anesthesia Angiotensin converting enzyme gene Blood Pressure Catecholamines - blood Female Hemodynamics Humans hypertension Hypertension - blood Hypertension - enzymology Hypertension - physiopathology intratracheal complications intubation Intubation, Intratracheal - adverse effects Male Middle Aged Myocardial Ischemia - etiology Myocardial Ischemia - genetics Peptidyl-Dipeptidase A - blood Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic |
Title | The effect of angiotensin-converting enzyme polymorphism on hemodynamic response to endotracheal intubation in hypertensive patients |
URI | https://www.tandfonline.com/doi/abs/10.1080/00365513.2016.1183259 https://www.ncbi.nlm.nih.gov/pubmed/27219718 https://search.proquest.com/docview/1825214904 |
Volume | 76 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtNAFB2FVkJsEG_CS4PEDrnyK2N72UKjqGoKqImI2Ixm7BmSRW2U2kh0zZfwpdx5xRM1iMImssayFfkc35fP3IvQm6SQeZKXVUBEGAZpxmTAZMZVSYDlcIqHehjM9IxM5unJYrQYDH55qqWu5Qfl1c59Jf-DKqwBrmqX7D8gu7kpLMAx4Au_gDD83hhjI8jQn_Prr6tGC9LrQIvJ11rSLOqrHxdCTWOANB-eqpqKAZAvxUVTmXH0b9dGKKunaIga8tS1avOs23G0HWdOD7mEnHXtFO-2IeulH92el3qTDPu-suV9G-putl-qKr2lnfq2v-qbfPRqgM-2gn3SXVv6slwFH52v9dYnrAkW3vr5kukK8LQLPrllW9mIiFbBGmsnrDUGcw35EPHNtRkXY2k58mxvYubzWDeemIlA1zyEk1QmRI22Udo-Am4D7JptTL7VkfvsAx3PT0_p7Hgxu4X246wYQYK_f3j0_mi88feQ5Kdub5jq2r7r1ltRz1ZP3D9nNjrCmd1Dd21qgg8Nz-6jgagfoNtTK754iH4C3bChG24k3k03bOiGfbrhpsYe3bCjG24b7NMN93SDQ-zTDTu6PULz8fHs3SSwQzyCMiGkVa9_HkeiDHlGeJhxKeOEFCyOIqZKMzIpGZwjkpMcjquKCJUjkyrOopQRyBYeo726qcVThGWVVeBORhz8TBoKiLTjIuMig-BLhCQWQ3TgHjL9Znq10KhvgatRoQoValEZosKHgra6SCbNRBua_OXa1w43ChZZfWZjtWi6SwoZO8TEaRGmQ_TEALr5O3EGEQKEg89ucPVzdKd_K16gvXbdiZcQAbf8laXgb1wOuEU |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | EBSCOhost |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effect+of+angiotensin-converting+enzyme+polymorphism+on+hemodynamic+response+to+endotracheal+intubation+in+hypertensive+patients&rft.jtitle=Scandinavian+journal+of+clinical+and+laboratory+investigation&rft.au=Wang%2C+Jun&rft.au=Wang%2C+Zhi-Ping&rft.au=Wang%2C+Hao-Xing&rft.au=Shao%2C+Mu-Qing&rft.date=2016-07-03&rft.eissn=1502-7686&rft.volume=76&rft.issue=5&rft.spage=368&rft.epage=372&rft_id=info:doi/10.1080%2F00365513.2016.1183259&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0036-5513&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0036-5513&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0036-5513&client=summon |