Taste masking of azithromycin by resin complex and sustained release through interpenetrating polymer network with functionalized biopolymers

• Published in: Drug development and industrial pharmacy Vol. 43; no. 5; p. 732
• Main Authors: Rajesh, A Michael, Popat, Kiritkumar Mangaldas
• Format: Journal Article
• Language: English
• Published: England 04.05.2017
• Subjects: Adolescent; Adult; Azithromycin - chemistry; Biopolymers - chemistry; Chemistry, Pharmaceutical - methods; Chitosan - chemistry; Delayed-Action Preparations - chemistry; Diffusion; Drug Liberation - drug effects; Female; Humans; Hydrogen-Ion Concentration; Ion Exchange Resins - chemistry; Male; Sepharose - chemistry; Taste - drug effects; Taste Perception - drug effects; Young Adult; functionalized biopolymers; Ion exchange resins; sustained release; taste masking; interpenetrating polymer network

The objective was to evaluate taste masking of azithromycin (AZI) by ion exchange resins (IERs) and the formation of covalent semi interpenetrating polymer network (IPN) beads using chitosan (CS) and sodium carboxylated agarose (SCAG) for sustained release of drug. Methacrylic acid (MAA)-based IERs...