Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression - Du, Juan; Liu, Ruyun; Ma, Lin; Liu, Yue; Wei, Wei; Liu, Ning; Cao, Qiuhua; Yu, Jianqiang (Scientific reports, 2025)
Keywords: 631/154; 631/477; 692/699; Acetylation; Acetylation - drug effects; Animals; Antibodies; Antidepressants; Antidepressive Agents - pharmacology; Chromatin; DELTA protein; Depression; Depression - drug therapy; Depression - genetics; Depression - metabolism; DNA methylation; Epigenetics; Ethics; Experiments; Gene Expression Regulation - drug effects; Gene set enrichment analysis; Genes; Glutamate receptors; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Histone acetylation; Histone deacetylase; Histone Deacetylase Inhibitors - pharmacology; Histone deacetylase-5 inhibitor; Histone Deacetylases - genetics; Histone Deacetylases - metabolism; Histones - metabolism; Humanities and Social Sciences; Laboratory animals; Life sciences; Male; Mental depression; Mice; Mice, Inbred C57BL; multidisciplinary; Pathogenesis; Pharmacy; Promoter Regions, Genetic; Science; Science (multidisciplinary); Synaptic depression; Synaptic transmission; T2943; Transcription factors; Epigenetics; Depression; Histone acetylation; Histone deacetylase-5 inhibitor; T2943