Formulation, optimization, and characterization of whey protein isolate nanocrystals for celecoxib delivery

• Published in: Journal of microencapsulation Vol. 38; no. 5; pp. 314 - 323
• Main Authors: Farooq, Muhammad Asim, Jabeen, Amna, Wang, Bo
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.07.2021
• Subjects: Biological Availability; cancer therapy; Celecoxib; Celecoxib - administration & dosage; Cyclooxygenase 2 Inhibitors - administration & dosage; Drug Compounding; Drug Delivery Systems; Drug Liberation; food proteins; Freeze Drying; Nanoparticles; Particle Size; Protein Conformation; Solubility; Ultrasonics; Whey Proteins - chemistry; cancer therapy; solubility; food proteins; Celecoxib

Current study aimed to improve the solubility and release profile of the celecoxib for cancer application. However, the low water solubility of celecoxib limited its application for cancer chemotherapy. Hence, new drug delivery-based approaches are compulsory for the efficient delivery of hydrophobi...