Should the sympathetic nervous system be a target to improve cardiometabolic risk in obesity?

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 309; no. 2; pp. H244 - H258
• Main Authors: Lambert, Elisabeth A., Straznicky, Nora E., Dixon, John B., Lambert, Gavin W.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.07.2015
• Subjects: Adipokines - metabolism; Adiposity; Animals; Cardiovascular disease; Cardiovascular Diseases - etiology; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - physiopathology; Cardiovascular Diseases - prevention & control; Humans; Inflammation Mediators - metabolism; Intra-Abdominal Fat - metabolism; Intra-Abdominal Fat - physiopathology; Metabolic syndrome; Nervous system; Neural Inhibition; Obesity; Obesity - complications; Obesity - metabolism; Obesity - physiopathology; Obesity - therapy; Physiology; Prognosis; Risk Factors; Signal Transduction; Sympathetic Nervous System - metabolism; Sympathetic Nervous System - physiopathology; sympathetic nervous system; obesity

The sympathetic nervous system (SNS) plays a key role in both cardiovascular and metabolic regulation; hence, disturbances in SNS regulation are likely to impact on both cardiovascular and metabolic health. With excess adiposity, in particular when visceral fat accumulation is present, sympathetic a...