Aberrant methylation of nucleotide excision repair genes is associated with chronic arsenic poisoning

• Published in: Biomarkers Vol. 22; no. 5; pp. 429 - 438
• Main Authors: Zhang, Aihua, Li, Huiyao, Xiao, Yun, Chen, Liping, Zhu, Xiaonian, Li, Jun, Ma, Lu, Pan, Xueli, Chen, Wen, He, Zhini
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.07.2017
• Subjects: Adult; arsenic exposure; Arsenic Poisoning - genetics; biomarkers; Case-Control Studies; DNA Methylation; DNA Repair - genetics; DNA-Binding Proteins - genetics; Endonucleases - genetics; ERCC1; ERCC2; Female; Humans; Lymphocytes - chemistry; Male; Middle Aged; Skin - pathology; Skin Diseases - chemically induced; Skin Diseases - pathology; Xeroderma Pigmentosum Group D Protein - genetics; XPC; DNA methylation; XPC; arsenic exposure; ERCC1; biomarkers; ERCC2

Objective: To define whether aberrant methylation of DNA repair genes is associated with chronic arsenic poisoning. Methods: Hundred and two endemic arsenicosis patients and 36 healthy subjects were recruited. Methylight and bisulfite sequencing (BSP) assays were used to examine the methylation stat...