Profiling of the Three Circulating Monocyte Subpopulations in Human Obesity

• Published in: The Journal of immunology (1950) Vol. 194; no. 8; pp. 3917 - 3923
• Main Authors: Devêvre, Estelle F, Renovato-Martins, Mariana, Clément, Karine, Sautès-Fridman, Catherine, Cremer, Isabelle, Poitou, Christine
• Format: Journal Article
• Language: English
• Published: United States Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists 15.04.2015
• Subjects: Adult; CX3C Chemokine Receptor 1; Female; Gene Expression Profiling; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; GPI-Linked Proteins - immunology; Humans; Immunology; Inflammation Mediators - immunology; Innate immunity; Life Sciences; Lipopolysaccharide Receptors - immunology; Lipopolysaccharides - pharmacology; Male; Monocytes - immunology; Monocytes - pathology; Obesity; Receptors, CCR2 - immunology; Receptors, CCR5 - immunology; Receptors, Chemokine - immunology; Receptors, IgG - immunology; Toll-Like Receptor 4 - agonists; Toll-Like Receptor 4 - immunology; Toll-Like Receptor 8 - agonists; Toll-Like Receptor 8 - immunology

Three subpopulations of circulating monocytes have been described: CD142+CD16− (classical monocytes [CM]), CD142+CD16+ (intermediate monocytes [IM]), and CD14+CD162+ (nonclassical monocytes [NCM]). We previously showed that obesity is associated with an increased proportion of IM and NCM. Our object...