Employing photoacoustic spectroscopy in the evaluation of the skin permeation profile of emulsion containing antioxidant phenolic-rich extract of Melochia arenosa

• Published in: Pharmaceutical biology Vol. 54; no. 1; pp. 139 - 145
• Main Authors: Tunin, Luana Magri, Borghi, Fernanda Belincanta, Nogueira, Ana Claudia, Higachi, Luciana, Barbosa, Décio Sabbatini, Baesso, Mauro Luciano, Hernandes, Luzmarina, Diniz, Andréa, Torrado Truiti, Maria da Conceição
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 02.01.2016
• Subjects: Administration, Cutaneous; Animals; Antioxidants - administration & dosage; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - metabolism; Central composite design; Emulsions; Humans; Male; Malvaceae - chemistry; Neutrophils - drug effects; Neutrophils - metabolism; oxidative stress; Permeability; Phenols - administration & dosage; Phenols - chemistry; Phenols - isolation & purification; Phenols - metabolism; Photoacoustic Techniques; Phytotherapy; Plant Components, Aerial; Plant Extracts - administration & dosage; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - metabolism; Plants, Medicinal; Rats, Wistar; Reactive Oxygen Species - metabolism; Respiratory Burst - drug effects; Skin - metabolism; Skin Absorption; skin care; skin penetration; Spectrum Analysis; Time Factors; Central composite design; skin care; skin penetration; oxidative stress

Context: Oxidative stress is an important factor modulating skin alterations. Melochia arenosa Benth. (Malvaceae) is a Brazilian plant with antimicrobial activity and antioxidant potential. Objective: The objective of this study is to develop a topical formulation containing antioxidant phenolic-ric...