Pharmacokinetic study of the prokinetic ABCs liquiritigenin, naringenin and hesperitin following the oral administration of Si-Ni-San decoction to functional dyspepsia patients

• Published in: Xenobiotica Vol. 49; no. 6; pp. 708 - 717
• Main Authors: Huang, Xi, Xu, Jianjun, He, Juan, Shi, Shaoqi, Yan, Hongbin, Wang, Jian, Ren, Ping
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.06.2019
• Subjects: Administration, Oral; Adult; Chromatography, Liquid; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - therapeutic use; Dyspepsia - drug therapy; Female; Flavanones - blood; Flavanones - chemistry; Flavanones - pharmacokinetics; functional dyspepsia; Gastrointestinal Motility - drug effects; Hesperidin - blood; Hesperidin - chemistry; Hesperidin - pharmacokinetics; Humans; Male; Middle Aged; pharmacokinetic; prokinetics; Si-Ni-San decoction; Sulfamethoxazole - chemistry; prokinetics; functional dyspepsia; pharmacokinetic; Si-Ni-San decoction

1. The pharmacokinetics (PKs) analysis of compounds absorbed after the oral administration of Si-Ni-San (SNS) decoction to functional dyspepsia (FD) patients was designed to detect whether the effects were similar to prokinetics administered to healthy rats, without ethical limitation. 2. First, the...