Gestational bisphenol A exposure alters energy homeostasis and adult hypothalamic neurogenesis in female mice

• Published in: Scientific reports Vol. 14; no. 1; pp. 16082 - 11
• Main Authors: Feighan, Kira M., Nesan, Dinushan, Kurrasch, Deborah M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1488/1562; 631/378/368/2431; 692/163; Animals; Benzhydryl Compounds - toxicity; Bisphenol A; Body weight gain; Diet; Diet, High-Fat - adverse effects; Energy balance; Energy Metabolism - drug effects; Female; Females; Gliogenesis; High fat diet; Homeostasis; Homeostasis - drug effects; Hormones; Humanities and Social Sciences; Hypothalamus; Hypothalamus (ventromedial); Hypothalamus - drug effects; Hypothalamus - metabolism; Intrauterine exposure; Male; Mice; multidisciplinary; Neural stem cells; Neurogenesis; Neurogenesis - drug effects; Nutrient deficiency; Phenols - toxicity; Pregnancy; Prenatal experience; Prenatal Exposure Delayed Effects - chemically induced; Progenitor cells; Science; Science (multidisciplinary)

Regulation of physiological homeostasis, including energy balance, is thought to be modified by low levels of adult neurogenesis in the hypothalamus. Hormones such as oestradiol can influence both embryonic and adult hypothalamic neurogenic programs, demonstrating a sensitivity of hypothalamic neura...