Gestational bisphenol A exposure alters energy homeostasis and adult hypothalamic neurogenesis in female mice

• Published in: Scientific reports Vol. 14; no. 1; pp. 16082 - 11
• Main Authors: Feighan, Kira M., Nesan, Dinushan, Kurrasch, Deborah M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1488/1562; 631/378/368/2431; 692/163; Animals; Benzhydryl Compounds - toxicity; Bisphenol A; Body weight gain; Diet; Diet, High-Fat - adverse effects; Energy balance; Energy Metabolism - drug effects; Female; Females; Gliogenesis; High fat diet; Homeostasis; Homeostasis - drug effects; Hormones; Humanities and Social Sciences; Hypothalamus; Hypothalamus (ventromedial); Hypothalamus - drug effects; Hypothalamus - metabolism; Intrauterine exposure; Male; Mice; multidisciplinary; Neural stem cells; Neurogenesis; Neurogenesis - drug effects; Nutrient deficiency; Phenols - toxicity; Pregnancy; Prenatal experience; Prenatal Exposure Delayed Effects - chemically induced; Progenitor cells; Science; Science (multidisciplinary)
• DOI: 10.1038/s41598-024-66726-2
• ISSN: 2045-2322

Regulation of physiological homeostasis, including energy balance, is thought to be modified by low levels of adult neurogenesis in the hypothalamus. Hormones such as oestradiol can influence both embryonic and adult hypothalamic neurogenic programs, demonstrating a sensitivity of hypothalamic neural progenitor cells to endogenous hormones. Previously we showed that gestational exposure to environmental levels of the xenoestrogen bisphenol A (BPA) changed neural progenitor cell behaviors in the embryo; however, we did not examine if these changes were permanent to affect adult neurogenesis. Here we investigated whether adult neuro- and/or gliogenesis were altered in mice prenatally exposed to BPA and placed on a high-fat diet challenge. Gestationally exposed adult female mice on a standard diet gained less weight than non-BPA controls, whereas gestationally exposed BPA females on a high-fat diet gained more weight than controls. Males exposed to gestational BPA showed no differences in weight gain relative to control males. Concomitantly, adult neurogenesis was increased in the VMH, DMH, and PVN of adult female mice exposed to BPA on standard diet, suggesting that disrupted adult neurogenesis might perturb normal energy balance regulation in females. These results add to growing evidence that low-dose BPA exposure in utero causes changes to adult hypothalamic function.