LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis

• Published in: Journal of translational medicine Vol. 23; no. 1; pp. 475 - 25
• Main Authors: Li, Fudong, Shi, Yangyang, Chen, Jun, Sun, Jingchuan, Shi, Jiangang, Sun, Kaiqiang, Zheng, Bing
• Format: Journal Article
• Language: English
• Published: England BMC 25.04.2025
• Subjects: Animals; Apoptosis; Apoptosis - genetics; Efferocytosis; Extracellular Matrix - metabolism; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Intervertebral disc degeneration; Intervertebral Disc Degeneration - genetics; Intervertebral Disc Degeneration - metabolism; Intervertebral Disc Degeneration - pathology; LGR6; Macrophages; Macrophages - metabolism; Macrophages - pathology; Male; Mice; Nucleus pulposus; Nucleus Pulposus - metabolism; Nucleus Pulposus - pathology; Phagocytosis; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Efferocytosis; Intervertebral disc degeneration; Nucleus pulposus; LGR6; Macrophages; Apoptosis

Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain, characterized by extracellular matrix (ECM) degradation, excessive inflammation activation, and increased cell apoptosis. LGR6, a receptor known for its role in tissue regeneration, has recently been implicated in m...