LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis - Li, Fudong; Shi, Yangyang; Chen, Jun; Sun, Jingchuan; Shi, Jiangang; Sun, Kaiqiang; Zheng, Bing (Journal of translational medicine, 2025)
Keywords: Animals; Apoptosis; Apoptosis - genetics; Efferocytosis; Extracellular Matrix - metabolism; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Intervertebral disc degeneration; Intervertebral Disc Degeneration - genetics; Intervertebral Disc Degeneration - metabolism; Intervertebral Disc Degeneration - pathology; LGR6; Macrophages; Macrophages - metabolism; Macrophages - pathology; Male; Mice; Nucleus pulposus; Nucleus Pulposus - metabolism; Nucleus Pulposus - pathology; Phagocytosis; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Efferocytosis; Intervertebral disc degeneration; Nucleus pulposus; LGR6; Macrophages; Apoptosis