Safety of the Combination of Intensive Cholesterol-Lowering Therapy with Oral Anticoagulation Medication in Elderly Patients with Atrial Fibrillation A Randomized, Double-Blind, Placebo-Controlled Study

• Published in: Drugs & aging Vol. 26; no. 7; pp. 585 - 593
• Main Authors: Enajat, Morteza, Teerenstra, Steven, van Kuilenburg, Janet T., van Sorge-Greve, Aty H. N., Albers-Akkers, Marjo T. H., Verheugt, Freek W. A., Pop, Gheorghe A. M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.01.2009; Adis International; Springer Nature B.V
• Subjects: Administration, Oral; Aged; Aged, 80 and over; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - adverse effects; Anticholesteremic Agents - administration & dosage; Anticholesteremic Agents - adverse effects; Anticoagulants - administration & dosage; Anticoagulants - adverse effects; Aspirin; Atrial Fibrillation - complications; Atrial Fibrillation - drug therapy; Biological and medical sciences; Cardiac arrhythmia; Cardiac dysrhythmias; Cardiology. Vascular system; Cholesterol; Cytochrome; Disease prevention; Dose-Response Relationship, Drug; Double-Blind Method; Drug dosages; Drug Interactions; Drug Therapy, Combination; Endpoint Determination; Enzymes; Female; Geriatrics/Gerontology; Heart; Hemorrhage - etiology; High density lipoprotein; Humans; Internal Medicine; Laboratories; Lipoproteins; Liver; Magnetic resonance imaging; Male; Medical sciences; Medication Adherence; Medicine; Medicine & Public Health; Original Research Article; Patients; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacotherapy; Placebo Effect; Stroke; Thromboembolism; International Normalize Ratio; Atorvastatin; Warfarin; Atrial Fibrillation; Ezetimibe; Human; Drug; Arrhythmia; Toxicity; Atrial fibrillation; Oral administration; Cardiovascular disease; Anticoagulant; Review; Excitability disorder; Randomization; Treatment; Heart disease; Placebo; Double blind study; Safety; Elderly; Antilipemic agent

Background The incidence of atrial fibrillation (AF) is very high in the elderly, and often oral anticoagulation (OAC) is indicated to prevent thromboembolism. Objective The aim of this study was to evaluate the safety of combining intensive cholesterol-lowering therapy with OAC in elderly patients...