Impact of the IL-17F, IL-23 and IL-23R on susceptibility and phenotype of systemic lupus erythematosus

• Published in: Autoimmunity (Chur, Switzerland) Vol. 49; no. 6; pp. 373 - 382
• Main Authors: Paradowska-Gorycka, Agnieszka, Sowinska, Anna, Stypinska, Barbara, Grobelna, Malwina Katarzyna, Walczyk, Marcela, Olesinska, Marzena, Piotrowski, Piotr, Jagodziński, Paweł Piotr
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.09.2016
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; Association study; Autoantibodies - blood; Autoantibodies - immunology; Biomarkers; Case-Control Studies; cytokine; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Interleukin-17 - genetics; Interleukin-23 - genetics; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - etiology; Male; Middle Aged; Odds Ratio; pathogenesis; Phenotype; Poland; Polymorphism, Single Nucleotide; polymorphisms; Receptors, Interleukin - genetics; Risk; SLE; Young Adult; cytokine; Association study; pathogenesis; SLE; polymorphisms

Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE...