Endogenous Airway Acidification . Implications for Asthma Pathophysiology

• Published in: American journal of respiratory and critical care medicine Vol. 161; no. 3; pp. 694 - 699
• Main Authors: HUNT, JOHN F, FANG, KEZHONG, MALIK, RAJESH, SNYDER, ASHLEY, MALHOTRA, NEIL, PLATTS-MILLS, THOMAS A. E, GASTON, BENJAMIN
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 01.03.2000; American Lung Association
• Subjects: Acid-Base Equilibrium - physiology; Airway Resistance - physiology; Apoptosis - physiology; Asthma - physiopathology; Biological and medical sciences; Bronchial Hyperreactivity - physiopathology; Chronic obstructive pulmonary disease, asthma; Eosinophils - physiology; Humans; Hydrogen-Ion Concentration; Medical sciences; Nitric Oxide - physiology; Pneumology; Respiratory Mucosa - physiopathology; Nitrogen oxide; Human; Corticosteroid; Respiratory disease; Pathogenesis; Antiinflammatory agent; Exploration; Asthma; Respiratory tract; Chemotherapy; Treatment; Nitric oxide; pH; Obstructive pulmonary disease
• ISSN: 1073-449X; 1535-4970
• DOI: 10.1164/ajrccm.161.3.9911005

Airway concentrations of many reactive nitrogen and oxygen species are high in asthma. The stability and bioactivities of these species are pH-dependent; however, the pH of the airway during acute asthma has not previously been studied. As with gastric and urinary acidification, asthmatic airway aci...