Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial - Liu, Yixian; Li, Xiaoyu; Zhang, Mengyu; Men, Yuchun; Wang, Ying; Zhu, Xiaohong; Zheng, Li (Drug design, development and therapy, 2025)
Keywords: Administration, Oral; Adult; Asian People; Calories; Cancer therapies; Clinical Trial Report; Clinical trials; Cross-Over Studies; Drinking water; Drug administration; Drug dosages; Drug resistance; East Asian People; Fasting; FDA approval; Female; Food; food effects; Food-Drug Interactions; Growth factors; ha121-28; Healthy Volunteers; Humans; Kinases; Lung cancer; Male; Mass spectrometry; Middle Aged; Mutation; Pharmacokinetics; Protein Kinase Inhibitors - administration & dosage; Protein Kinase Inhibitors - adverse effects; Protein Kinase Inhibitors - pharmacokinetics; Protein-Tyrosine Kinases - antagonists & inhibitors; Protein-Tyrosine Kinases - metabolism; Safety; Scientific imaging; Signal transduction; Tablets; Tyrosine; tyrosine kinase inhibitor; Tyrosine Kinase Inhibitors; Vascularization; Young Adult; China; pharmacokinetics; HA121-28; tyrosine kinase inhibitor; Food effects; safety