Impaired orexin receptor expression in the Kölliker-Fuse nucleus in sudden infant death syndrome: possible involvement of this nucleus in arousal pathophysiology

• Published in: Neurological research (New York) Vol. 38; no. 8; p. 706
• Main Authors: Lavezzi, Anna Maria, Ferrero, Stefano, Roncati, Luca, Matturri, Luigi, Pusiol, Teresa
• Format: Journal Article
• Language: English
• Published: England 02.08.2016
• Subjects: Female; Glial Fibrillary Acidic Protein - metabolism; Humans; Infant; Kolliker-Fuse Nucleus - metabolism; Kolliker-Fuse Nucleus - pathology; Kolliker-Fuse Nucleus - physiopathology; Male; Neurons - metabolism; Orexin Receptors - metabolism; Phosphopyruvate Hydratase - metabolism; Sudden Infant Death - pathology; GFAP= glial fibrillary acid protein; BDNF= brain-derived neurotrophic factor; LC= locus coeruleus; SIDS; Neuropathology; Brainstem; CPAP= continuous positive airway pressure; F/PFc= Facial/Parafacial complex; KFN= Kölliker–Fuse nucleus; NeuN= neuronal nuclear antigen; ILN= intermediolateral nucleus; Kölliker–Fuse nucleus; Ox= Orexin; TSN= tractus solitarius nucleus; Arousal; RN= respiratory network; GC/MS= gas chromatography/mass spectrometry; OxR= Orexin receptor; SIDS= sudden infant death syndrome; pBN= pre-Bötzinger nucleus; Orexin; ABC= avidin-biotin complex

As well known, the sudden infant death syndrome (SIDS) is characterized by the sudden death of a seemingly healthy infant during sleep, frequently resulted from a deficit in arousal phase. Awakening from sleep requires a fully developed and functioning neuronal respiratory network to modulate the ve...