3D Imaging Resolves Human Pancreatic Duct-β-Cell Clusters During Cystic Change

• Published in: Diabetes (New York, N.Y.) Vol. 74; no. 5; pp. 734 - 748
• Main Authors: Lee, Chih-Yuan, Kuo, Ting-Chun, Chou, Ya-Hsien, Peng, Shih-Jung, Hsiao, Fu-Ting, Chung, Mei-Hsin, Lo, Li-Wen, Shen, Chia-Ning, Chien, Hung-Jen, Chang, Hsiu-Pi, Chen, Chien-Chia, Jeng, Yung-Ming, Tien, Yu-Wen, Tang, Shiue-Cheng
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.05.2025
• Subjects: Adult; Aged; Beta cells; Cadavers; Cytokeratin; Diabetes; Epithelium; Female; Humans; Imaging, Three-Dimensional - methods; Immunohistochemistry; Insulin; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Islet Studies; Keratin-7 - metabolism; Male; Microcysts; Middle Aged; Pancreas; Pancreatic Cyst - diagnostic imaging; Pancreatic Cyst - metabolism; Pancreatic Cyst - pathology; Pancreatic Ducts - diagnostic imaging; Pancreatic Ducts - metabolism; Pancreatic Ducts - pathology; Pancreatic Neoplasms - diagnostic imaging; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology

Pancreatic cystic changes in adults are increasingly identified through advanced cross-sectional imaging. However, the impact of initial/intra-lobular epithelial remodeling on the local β-cell population remains unclear. In this study, we examined 10 human cadaveric donor pancreases (tail and body r...