Lymphopenia-Driven Homeostatic Regulation of Naive T Cells in Elderly and Thymectomized Young Adults

• Published in: The Journal of immunology (1950) Vol. 189; no. 12; pp. 5541 - 5548
• Main Authors: Sauce, Delphine, Larsen, Martin, Fastenackels, Solène, Roux, Antoine, Gorochov, Guy, Katlama, Christine, Sidi, Daniel, Sibony-Prat, Joyce, Appay, Victor
• Format: Journal Article
• Language: English
• Published: United States Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists 15.12.2012
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Cell Differentiation - immunology; Female; Homeostasis - immunology; Human immunodeficiency virus; Humans; Immunologic Memory - immunology; Immunology; Life Sciences; Lymphopenia - pathology; Male; Middle Aged; T-Lymphocyte Subsets - cytology; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - pathology; Thymectomy; Young Adult

Reduced thymopoiesis and continuous mobilization of naive T cells into the effector–memory pool can lead to severe alterations of the naive T cell compartment. However, maintenance of the naive T cell population is essential to mount effective immune responses. Evidence of homeostatic regulation of...