Familial Mediterranean Fever In Lebanon: Founder Effects For Different MEFV Mutations
Summary Haplotype analysis of 376 Familial Mediterranean Fever (FMF) patients and 100 controls from Lebanon was performed using 4 microsatellite loci to study founder effects for the five most frequent mutations within the MEFV gene (M694V, M694I, V726A, M680I and E148Q). Each of these mutations was...
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Published in | Annals of human genetics Vol. 72; no. 1; pp. 41 - 47 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Oxford, UK
Blackwell Publishing Ltd
01.01.2008
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Abstract | Summary
Haplotype analysis of 376 Familial Mediterranean Fever (FMF) patients and 100 controls from Lebanon was performed using 4 microsatellite loci to study founder effects for the five most frequent mutations within the MEFV gene (M694V, M694I, V726A, M680I and E148Q).
Each of these mutations was associated with a particular haplotype that was less frequent among controls, confirming that they have probably arisen from unique mutation events and that the carrier chromosomes derived from a common ancestor. The estimated ages of the most recent common ancestor for each of the 5 mutations, using the ESTIAGE program, were 7000, 8500, 15000, 23000 and 30000 years for M694V, M694I, V726A, M680I and E148Q, respectively. Varying the mutation rate at one of the markers led to younger age estimates, but the mutation E148Q remained the oldest one.
Comparison of haplotype distributions among the different Lebanese religious groups confirmed that Muslim sub‐populations (Shiites and Sunnites) as well as Christian ones, including Armenians who were formerly settled in the South‐Eastern part of Asia Minor (Cilicia), are all derived from an ancient common ancestral population in which most of the MEFV mutations were already present with their respective associated haplotypes. |
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AbstractList | Summary
Haplotype analysis of 376 Familial Mediterranean Fever (FMF) patients and 100 controls from Lebanon was performed using 4 microsatellite loci to study founder effects for the five most frequent mutations within the MEFV gene (M694V, M694I, V726A, M680I and E148Q).
Each of these mutations was associated with a particular haplotype that was less frequent among controls, confirming that they have probably arisen from unique mutation events and that the carrier chromosomes derived from a common ancestor. The estimated ages of the most recent common ancestor for each of the 5 mutations, using the ESTIAGE program, were 7000, 8500, 15000, 23000 and 30000 years for M694V, M694I, V726A, M680I and E148Q, respectively. Varying the mutation rate at one of the markers led to younger age estimates, but the mutation E148Q remained the oldest one.
Comparison of haplotype distributions among the different Lebanese religious groups confirmed that Muslim sub‐populations (Shiites and Sunnites) as well as Christian ones, including Armenians who were formerly settled in the South‐Eastern part of Asia Minor (Cilicia), are all derived from an ancient common ancestral population in which most of the MEFV mutations were already present with their respective associated haplotypes. Haplotype analysis of 376 Familial Mediterranean Fever (FMF) patients and 100 controls from Lebanon was performed using 4 microsatellite loci to study founder effects for the five most frequent mutations within the MEFV gene (M694V, M694I, V726A, M680I and E148Q). Each of these mutations was associated with a particular haplotype that was less frequent among controls, confirming that they have probably arisen from unique mutation events and that the carrier chromosomes derived from a common ancestor. The estimated ages of the most recent common ancestor for each of the 5 mutations, using the ESTIAGE program, were 7000, 8500, 15000, 23000 and 30000 years for M694V, M694I, V726A, M680I and E148Q, respectively. Varying the mutation rate at one of the markers led to younger age estimates, but the mutation E148Q remained the oldest one. Comparison of haplotype distributions among the different Lebanese religious groups confirmed that Muslim sub‐populations (Shiites and Sunnites) as well as Christian ones, including Armenians who were formerly settled in the South‐Eastern part of Asia Minor (Cilicia), are all derived from an ancient common ancestral population in which most of the MEFV mutations were already present with their respective associated haplotypes. Haplotype analysis of 376 Familial Mediterranean Fever (FMF) patients and 100 controls from Lebanon was performed using 4 microsatellite loci to study founder effects for the five most frequent mutations within the MEFV gene (M694V, M694I, V726A, M680I and E148Q). Each of these mutations was associated with a particular haplotype that was less frequent among controls, confirming that they have probably arisen from unique mutation events and that the carrier chromosomes derived from a common ancestor. The estimated ages of the most recent common ancestor for each of the 5 mutations, using the ESTIAGE program, were 7000, 8500, 15000, 23000 and 30000 years for M694V, M694I, V726A, M680I and E148Q, respectively. Varying the mutation rate at one of the markers led to younger age estimates, but the mutation E148Q remained the oldest one. Comparison of haplotype distributions among the different Lebanese religious groups confirmed that Muslim sub-populations (Shiites and Sunnites) as well as Christian ones, including Armenians who were formerly settled in the South-Eastern part of Asia Minor (Cilicia), are all derived from an ancient common ancestral population in which most of the MEFV mutations were already present with their respective associated haplotypes. |
Author | Jalkh, Nadine Chouery, Eliane Delague, Valérie Génin, Emmanuelle Idrac, Charles‐Antoine Medlej‐Hashim, Myrna Mégarbané, André Serre, Jean‐Louis |
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References | 1998; 27 1997; 90 2004; 41 2004; 75 1958; 102 1997; 44 1967; 43 2000; 67 1988; 16 2001; 9 2004; 24 1979; 3 1999; 64 1998; 91 1998; 7 2005; 48 1998; 6 2001; 68 2003; 73 1998; 77 1998; 351 1998; 25 e_1_2_5_17_1 e_1_2_5_9_1 Samuels J. (e_1_2_5_14_1) 1998; 77 e_1_2_5_16_1 e_1_2_5_8_1 e_1_2_5_11_1 e_1_2_5_23_1 e_1_2_5_10_1 e_1_2_5_6_1 e_1_2_5_13_1 Touitou I. (e_1_2_5_21_1) 1998; 25 e_1_2_5_5_1 Cazeneuve C. (e_1_2_5_7_1) 2000; 67 e_1_2_5_12_1 e_1_2_5_22_1 e_1_2_5_4_1 e_1_2_5_3_1 e_1_2_5_2_1 Serre J. L. (e_1_2_5_15_1) 1979; 3 e_1_2_5_19_1 e_1_2_5_18_1 e_1_2_5_20_1 |
References_xml | – volume: 3 start-page: 251 year: 1979 end-page: 255 article-title: HLA markers in six Lebanese religious subpopulations publication-title: Tissue Antigens – volume: 9 start-page: 473 year: 2001 end-page: 483 article-title: The spectrum of Familial Mediterranean Fever (FMF) mutations publication-title: Eur J Hum Genet – volume: 6 start-page: 95 year: 1998 end-page: 97 article-title: Genotype‐phenotype correlation in Jewish patients suffering from familial Mediterranean fever (FMF) publication-title: Eur J Hum Genet – volume: 351 start-page: 659 year: 1998 end-page: 664 article-title: Familial Mediterranean fever publication-title: Lancet – volume: 44 start-page: 280 year: 1997 end-page: 291 article-title: A high‐resolution genetic map of the familial Mediterranean fever candidate region allows identification of haplotype‐sharing among ethnic groups publication-title: Genomics – volume: 25 start-page: 916 year: 1998 end-page: 919 article-title: Familial Mediterranean Fever Clinical and Genetic features in Druzes and in Iraqi Jews: A preliminary study publication-title: J Rhum – volume: 41 start-page: 445 year: 2004 end-page: 449 article-title: Estimating the age of rare disease mutations: the example of Triple‐A syndrome publication-title: J Med Genet – volume: 91 start-page: 603 year: 1998 end-page: 606 article-title: Pyrin/marenostrin mutations in familial Mediterranean fever. publication-title: Q J Med – volume: 73 start-page: 1162 year: 2003 end-page: 1169 article-title: A comparison of bayesian methods for haplotype reconstruction from population genotype data publication-title: Am J Hum Genet – volume: 24 start-page: 194 year: 2004 end-page: 198 article-title: Infevers: An evolving mutation database for auto‐inflammatory syndromes publication-title: Hum Mutat – volume: 43 start-page: 227 year: 1967 end-page: 253 article-title: Familial Mediterranean fever. A survey of 470 cases and review of the literature publication-title: Am J Med – volume: 16 start-page: 1215 year: 1988 article-title: A simple salting out procedure for extracting DNA from human nucleated cells publication-title: Nucleic Acids Res – volume: 48 start-page: 412 year: 2005 end-page: 420 article-title: Familial Mediterranean fever (FMF) in Lebanon and Jordan: a population genetics study and report of three novel mutations publication-title: Eur J Med Genet – volume: 64 start-page: 949 year: 1999 end-page: 962 article-title: Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population publication-title: Am J Hum Genet – volume: 90 start-page: 797 year: 1997 end-page: 807 article-title: Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium publication-title: Cell – volume: 77 start-page: 268 year: 1998 end-page: 297 article-title: Familial Mediterranean fever at the Millennium publication-title: Rev Mol Med – volume: 68 start-page: 978 year: 2001 end-page: 989 article-title: A new statistical method for haplotype reconstruction from population data publication-title: Am J Hum Genet – volume: 7 start-page: 1317 year: 1998 end-page: 1325 article-title: Non‐founder mutations in the gene establish this gene as the cause of familial Mediterranean fever (FMF). publication-title: Hum Mol Genet – volume: 102 start-page: 50 year: 1958 end-page: 71 article-title: Familial Mediterranean Fever publication-title: Arch Intern Med – volume: 67 start-page: 1136 year: 2000 end-page: 1143 article-title: Identification of MEFV‐independent modifying genetic factors for Familial Mediterranean Fever publication-title: Am J Hum Genet – volume: 75 start-page: 282 year: 2004 end-page: 293 article-title: A population‐genetic test of founder effects and implications for Ashkenazi Jewish diseases publication-title: Am J Hum Genet – volume: 27 start-page: 92 year: 1998 end-page: 97 article-title: Familial Mediterranean fever: from the clinical syndrome to the cloning of the pyrin gene publication-title: Scand J Rheumatol – volume: 67 start-page: 1136 year: 2000 ident: e_1_2_5_7_1 article-title: Identification of MEFV‐independent modifying genetic factors for Familial Mediterranean Fever publication-title: Am J Hum Genet contributor: fullname: Cazeneuve C. – ident: e_1_2_5_5_1 doi: 10.1093/hmg/7.8.1317 – ident: e_1_2_5_20_1 doi: 10.1016/S0092-8674(00)80539-5 – ident: e_1_2_5_2_1 doi: 10.1086/302327 – ident: e_1_2_5_18_1 doi: 10.1086/319501 – ident: e_1_2_5_16_1 doi: 10.1086/423146 – volume: 3 start-page: 251 year: 1979 ident: e_1_2_5_15_1 article-title: HLA markers in six Lebanese religious subpopulations publication-title: Tissue Antigens contributor: fullname: Serre J. L. – ident: e_1_2_5_19_1 doi: 10.1086/379378 – ident: e_1_2_5_6_1 doi: 10.1093/qjmed/91.9.603 – volume: 25 start-page: 916 year: 1998 ident: e_1_2_5_21_1 article-title: Familial Mediterranean Fever Clinical and Genetic features in Druzes and in Iraqi Jews: A preliminary study publication-title: J Rhum contributor: fullname: Touitou I. – ident: e_1_2_5_3_1 doi: 10.1006/geno.1997.4860 – ident: e_1_2_5_9_1 doi: 10.1136/jmg.2003.017962 – ident: e_1_2_5_22_1 doi: 10.1038/sj.ejhg.5200658 – ident: e_1_2_5_17_1 doi: 10.1016/0002-9343(67)90167-2 – ident: e_1_2_5_11_1 doi: 10.1016/j.ejmg.2005.05.010 – volume: 77 start-page: 268 year: 1998 ident: e_1_2_5_14_1 article-title: Familial Mediterranean fever at the Millennium publication-title: Rev Mol Med contributor: fullname: Samuels J. – ident: e_1_2_5_23_1 doi: 10.1002/humu.20080 – ident: e_1_2_5_12_1 doi: 10.1093/nar/16.3.1215 – ident: e_1_2_5_10_1 doi: 10.1001/archinte.1958.00260190052007 – ident: e_1_2_5_13_1 doi: 10.1080/030097498440949 – ident: e_1_2_5_8_1 doi: 10.1038/sj.ejhg.5200170 – ident: e_1_2_5_4_1 doi: 10.1016/S0140-6736(97)09408-7 |
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Haplotype analysis of 376 Familial Mediterranean Fever (FMF) patients and 100 controls from Lebanon was performed using 4 microsatellite loci to study... Haplotype analysis of 376 Familial Mediterranean Fever (FMF) patients and 100 controls from Lebanon was performed using 4 microsatellite loci to study founder... |
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SubjectTerms | Alleles Case-Control Studies common ancestor Familial Mediterranean Fever - genetics Familial Mediterranean Fever - physiopathology FMF Founder Effect Gene Frequency Genetic Markers haplotype Haplotypes Humans Lebanon Microsatellite Repeats Mutation |
Title | Familial Mediterranean Fever In Lebanon: Founder Effects For Different MEFV Mutations |
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