Persistent changes in extracellular lactate dynamics following synaptic potentiation

• Published in: Neurobiology of learning and memory Vol. 175; p. 107314
• Main Authors: Bingul, D., Kalra, K., Murata, E.M., Belser, A., Dash, M.B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2020
• Subjects: Animals; Dentate Gyrus - metabolism; Electric Stimulation; Extracellular Space - metabolism; Glycolysis; Hippocampus; Lactate; Lactic Acid - metabolism; Long-term potentiation; Long-Term Potentiation - physiology; Neuronal Plasticity; Perforant Pathway; Rats; Synaptic plasticity; Glycolysis; Lactate; Long-term potentiation; Hippocampus; Synaptic plasticity

•Characterized how long term potentiation affects extracellular lactate dynamics.•Potentiation causes enhanced acute lactate response to neuronal activity.•Potentiation causes chronic increases in lactate availability.•Acute and chronic changes in lactate manifest ~24 h after synaptic potentiation....