Epigenome-wide DNA methylation signature of benzo[a]pyrene exposure and their mediation roles in benzo[a]pyrene-associated lung cancer development

• Published in: Journal of hazardous materials Vol. 416; p. 125839
• Main Authors: Meng, Hua, Li, Guyanan, Wei, Wei, Bai, Yansen, Feng, Yue, Fu, Ming, Guan, Xin, Li, Mengying, Li, Hang, Wang, Chenming, Jie, Jiali, Wu, Xiulong, He, Meian, Zhang, Xiaomin, Wei, Sheng, Li, Yangkai, Guo, Huan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2021
• Subjects: Benzo[a]pyrene; carcinogenesis; carcinogens; DNA; DNA methylation; enzyme-linked immunosorbent assay; Lung cancer; lung neoplasms; lungs; Mediation effect; meta-analysis; Plasma BPDE-Alb adducts; risk; EWAS; Lung cancer; INT; NDE; AUC; MRS; BPDE; PANTHER; SD; BPDE-Alb; QC; FDR; DNA methylation; Benzo[a]pyrene; MDS; BMI; GREAT; OR; Mediation effect; CI; EWMA; GO; ARNT; NIE; SVs; TE; CV; B[a]P; LC-1; PAHs; Plasma BPDE-Alb adducts; ELISA; LC-2; SVA

Benzo[a]pyrene (B[a]P) is a typical carcinogen associated with increased lung cancer risk, but the underlying mechanisms remain unclear. This study aimed to investigate epigenome-wide DNA methylation associated with B[a]P exposure and their mediation effects on B[a]P-lung cancer association in two l...