ICER-IIγ is a tumor suppressor that mediates the antiproliferative activity of cAMP

• Published in: Oncogene Vol. 17; no. 23; pp. 3015 - 3019
• Main Authors: RAZAVI, R, RAMOS, J. C, YEHIA, G, SCHLOTTER, F, MOLINA, C. A
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 10.12.1998; Nature Publishing Group
• Subjects: Biological and medical sciences; Brain tumors; Cell cycle; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Choriocarcinoma; Cyclic AMP; Cyclic AMP response element modulator; DNA biosynthesis; Fundamental and applied biological sciences. Psychology; Molecular and cellular biology; Pituitary; Regulatory sequences; Transcription factors; Tumor cells; Tumor suppressor genes; Human; Cell proliferation; Rodentia; Cyclic AMP; Carcinogenesis; Vertebrata; Regulation(control); Mammalia; Cell line; Mouse; Cell cycle; Tumor; Transcription factor; Tumor suppressor gene

The second messenger cAMP inhibits the proliferation of most cell types. The nuclear response of cAMP is mediated by transcription factors like the cAMP-Responsive Element Modulator (CREM) gene. One of the products of the CREM gene, the transcriptional repressor Inducible cAMP Early Repressor-IIγ (I...