RBP-J promotes cell growth and metastasis through regulating miR-182-5p-mediated Tiam1/Rac1/p38 MAPK axis in colorectal cancer

• Published in: Cellular signalling Vol. 87; p. 110103
• Main Authors: Li, Fang, Zhou, Ya-Dong, Liu, Jiao, Cai, Jiao-Di, Liao, Zhi-Ming, Chen, Guo-Qun
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.11.2021
• Subjects: Animals; Cell Cycle; Cell Proliferation - genetics; Colorectal cancer; Colorectal Neoplasms - pathology; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; miR-182-5p; p38 MAPK; p38 Mitogen-Activated Protein Kinases - metabolism; Rac1; rac1 GTP-Binding Protein - metabolism; RBP-J; T-Lymphoma Invasion and Metastasis-inducing Protein 1 - metabolism; Tiam1; Colorectal cancer; short hairpin RNA; Rac1; miR-182-5p; p38 MAPK; real-time quantitative PCR; RNA immunoprecipitation; RBP-J

RBP-J is involved in number of cellular processes. However, the potential mechanisms of RBP-J on colorectal cancer (CRC) development have not been clearly defined. In this study, we aimed to investigate the role and molecular mechanism of RBP-J in CRC. The expression levels of RBP-J and Tiam1 in CRC...