Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis

• Published in: Spine (Philadelphia, Pa. 1976) Vol. 36; no. 1; p. 37
• Main Authors: Nelson, Lesa M, Ward, Kenneth, Ogilvie, James W
• Format: Journal Article
• Language: English
• Published: United States 01.01.2011
• Subjects: Acetylserotonin O-Methyltransferase - genetics; Adolescent; Arylalkylamine N-Acetyltransferase - genetics; Case-Control Studies; Chi-Square Distribution; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; High-Throughput Nucleotide Sequencing; Humans; Melatonin - biosynthesis; Melatonin - genetics; Melatonin - metabolism; Odds Ratio; Oligonucleotide Array Sequence Analysis; Phenotype; Polymorphism, Single Nucleotide; Protein Kinase C-delta - genetics; Radiography; Receptor, Melatonin, MT1 - genetics; Risk Assessment; Risk Factors; Scoliosis - diagnostic imaging; Scoliosis - genetics; Scoliosis - metabolism; Signal Transduction - genetics; Tryptophan Hydroxylase - genetics; United States

Genetic association study investigating the association of genetic markers of melatonin signaling and biosynthesis with adolescent idiopathic scoliosis (AIS). To determine whether gene polymorphisms related to the melatonin signaling or biosynthesis pathways are associated with AIS. Data have been p...