Reduced YAP1 and FOLR1 in gliomas predict better response to chemotherapeutics
Gliomas harbouring mutations in IDH1 (isocitrate dehydrogenase 1) are characterized by greater sensitivity to chemotherapeutics. These mutants also exhibit diminished levels of transcriptional coactivator YAP1 (yes-associated protein 1). Enhanced DNA damage in IDH1 mutant cells, as evidenced by γH2A...
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Published in | Cellular signalling Vol. 109; p. 110738 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Inc
01.09.2023
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Subjects | |
Online Access | Get full text |
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