Tupaia orthoreovirus: The first successful isolation of a novel Mammalian orthoreovirus from treeshrews in Malaysia

• Published in: Journal of virological methods Vol. 337; p. 115189
• Main Authors: Siew, Zhen Yun, Ngai, Zi Ni, Wong, Siew Tung, Chew, Xin Yi, Tan, Boon Shing, Leong, Chee-Onn, Koh, Rhun Yian, Leong, Pooi Pooi, Voon, Kenny
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2025
• Subjects: A549 Cells; Animal Viruses; Animals; Apoptosis; Chlorocebus aethiops; Feces - virology; Genome, Viral; Humans; Malaysia; Oncolytic virus; One Health; Orthoreovirus, Mammalian - classification; Orthoreovirus, Mammalian - genetics; Orthoreovirus, Mammalian - isolation & purification; Phylogeny; Reoviridae Infections - veterinary; Reoviridae Infections - virology; Spinareoviridae; Treeshrew; Tupaia - virology; Urine - virology; Vero Cells; Zoonotic virus; Malaysia; Spinareoviridae; Animal Viruses; Oncolytic virus; Zoonotic virus; One Health; Treeshrew; Apoptosis

Treeshrews, which share a closer common ancestor with primates and flying lemurs than with rodents, have been proposed as a better animal model for biomedical research compared to traditional rodent models. Zoonotic viruses like Mammalian orthoreovirus (MRV) pose potential public health risks, but t...