An ex-vivo model for transsynovial drug permeation of intraarticular injectables in naive and arthritic synovium
Estimation of joint residence time of a drug is a key requirement for rational development of intraarticular therapeutics. There is a great need for a predictive model to reduce the high number of animal experiments in early stage development. Here, a Franz-cell based porcine ex-vivo permeation mode...
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Published in | Journal of controlled release Vol. 332; pp. 581 - 591 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
10.04.2021
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Subjects | |
Online Access | Get full text |
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