An ex-vivo model for transsynovial drug permeation of intraarticular injectables in naive and arthritic synovium

• Published in: Journal of controlled release Vol. 332; pp. 581 - 591
• Main Authors: Siefen, Tobias, Lokhnauth, John, Liang, Alfred, Larsen, Crilles Casper, Lamprecht, Alf
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.04.2021
• Subjects: Formulation development; Franz-cell; Joint residence time; Permeability; Synovitis; Formulation development; Synovitis; Joint residence time; Permeability; Franz-cell

Estimation of joint residence time of a drug is a key requirement for rational development of intraarticular therapeutics. There is a great need for a predictive model to reduce the high number of animal experiments in early stage development. Here, a Franz-cell based porcine ex-vivo permeation mode...