Association of Synergistetes and Cyclodipeptides with Periodontitis

• Published in: Journal of dental research Vol. 94; no. 10; pp. 1425 - 1431
• Main Authors: Marchesan, J.T., Morelli, T., Moss, K., Barros, S.P., Ward, M., Jenkins, W., Aspiras, M.B., Offenbacher, S.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.10.2015; SAGE PUBLICATIONS, INC
• Subjects: Bacteria; Biofilms; Chromatography; Community structure; Data analysis; Dental Plaque - microbiology; Deoxyribonucleic acid; Dipeptides - analysis; Disease; DNA; Dysbacteriosis; Fluids; Gas chromatography; Gas Chromatography-Mass Spectrometry; Generalized linear models; Gram-Negative Anaerobic Bacteria; Gram-Negative Bacterial Infections - complications; Gram-Negative Bacterial Infections - microbiology; Gum disease; Humans; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Metabolites; Metabolome; Metabolomics; Microbiomes; Microorganisms; Pathogens; Peptides, Cyclic - analysis; Periodontal diseases; Periodontitis; Periodontitis - etiology; Periodontitis - microbiology; Population studies; Principal components analysis; Regression analysis; Saliva; Saliva - chemistry; Saliva - microbiology; Scientific imaging; Spirochaetales; Studies; Synergistetes; United States > US; microbiology; bacteria; inflammation; clinical studies/trials; infectious disease(s); biofilm(s)

The purpose of this study was to evaluate the microbial community (MC) composition as it relates to salivary metabolites and periodontal clinical parameters in a 21-d biofilm-overgrowth model. Subjects (N = 168) were enrolled equally into 5 categories of periodontal status per the biofilm-gingival i...