Immunotherapeutic effects of allogeneic mesenchymal stem cells on systemic lupus erythematosus

• Published in: Lupus Vol. 29; no. 8; pp. 872 - 883
• Main Authors: Liu, Fang, Chen, Hui, Chen, Tao, Lau, Chak-sing, Yu, Fu-xun, Chen, Kun, Chen, Hou-ping, Pan, Run-sang, Chan, Godfrey Chi-Fung, Zhang, Xiang-yan, Nie, Ying-jie
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2020; Sage Publications Ltd
• Subjects: Animal models; Animals; Anti-DNA antibodies; B-Lymphocytes - metabolism; CD19 antigen; CD3 antigen; CD4 antigen; CD8 antigen; Disease Models, Animal; Dosage; Female; Graft-versus-host reaction; Green fluorescent protein; Lupus; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - therapy; Lymphocytes B; Major histocompatibility complex; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Mice; Mice, Inbred ICR; Mice, Inbred MRL lpr; Phenotypes; Proteinuria; Spleen; Stem cell transplantation; Stem cells; Systemic lupus erythematosus; T-Lymphocytes - metabolism; Transgenic mice; Ulcers; Autoimmune disease; mesenchymal stem cells (MSCs); systemic lupus erythematosus (SLE)

Mesenchymal stem cells have been applied to treat graft versus host disease as they have immunosuppressive ability and can overcome the major histocompatibility complex–histocompatibility barrier. The potential of allogeneic mesenchymal stem cells in treating systemic lupus erythematosus (SLE) was i...