Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration

• Published in: Spine (Philadelphia, Pa. 1976) Vol. 37; no. 1; p. 18
• Main Authors: Melrose, James, Shu, Cindy, Young, Cara, Ho, Ronald, Smith, Margaret M, Young, Allan A, Smith, Susan S, Gooden, Ben, Dart, Andrew, Podadera, Juan, Appleyard, Richard C, Little, Christopher B
• Format: Journal Article
• Language: English
• Published: United States 01.01.2012
• Subjects: ADAM Proteins - genetics; ADAM Proteins - metabolism; ADAMTS4 Protein; Animals; Collagen - genetics; Collagen - metabolism; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Intervertebral Disc - injuries; Intervertebral Disc - metabolism; Intervertebral Disc - pathology; Intervertebral Disc Degeneration - etiology; Intervertebral Disc Degeneration - metabolism; Intervertebral Disc Degeneration - pathology; Lumbar Vertebrae - pathology; Lumbar Vertebrae - physiopathology; Lumbar Vertebrae - surgery; Magnetic Resonance Imaging; Male; Metalloproteases - genetics; Metalloproteases - metabolism; Orchiectomy; Procollagen N-Endopeptidase - genetics; Procollagen N-Endopeptidase - metabolism; Proteoglycans - genetics; Proteoglycans - metabolism; RNA, Messenger - metabolism; Sheep; Stress, Mechanical

An investigation of mechanical destabilization of the lumbar ovine intervertebral disc (IVD) inducing IVD degeneration (IVDD) as determined by multiparameter outcome measures (magnetic resonance imaging [MRI], IVD composition, biomechanical testing, gene profiling, immunohistochemistry, and immunobl...