Subgingival Host-Microbial Interactions in Hyperglycemic Individuals

• Published in: Journal of dental research Vol. 99; no. 6; pp. 650 - 657
• Main Authors: Kumar, P.S., Monteiro, M.F., Dabdoub, S.M., Miranda, G.L., Casati, M.Z., Ribeiro, F.V., Cirano, F.R., Pimentel, S.P., Casarin, R.C.V.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.06.2020; SAGE PUBLICATIONS, INC
• Subjects: Bacteria; Biofilms; Chronic Periodontitis - therapy; Colonization; Cytokines; Dental Scaling; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Gingiva; Gingival Crevicular Fluid; Gum disease; Humans; Hyperglycemia; IL-1β; Immune system; Inflammation; Interleukin 10; Interleukin 17; Interleukin 6; Microbial Interactions; Microbiomes; Mutualism; Nucleotide sequence; Periodontitis; Ribosomal DNA; Risk factors; Root Planing; cytokine; interactome; microbiome; diabetes; 16S; periodontitis

Type 2 diabetes mellitus (T2DM) is an established risk factor for periodontitis, yet its contribution to creating host-bacterial disequilibrium in the subgingival crevice is poorly understood. The present investigation aimed to quantify the impact of hyperglycemia on host-bacterial interactions in e...