Safety pharmacology of acute MDMA administration in healthy subjects

• Published in: Journal of psychopharmacology (Oxford) Vol. 31; no. 5; p. 576
• Main Authors: Vizeli, Patrick, Liechti, Matthias E
• Format: Journal Article
• Language: English
• Published: United States 01.05.2017
• Subjects: Blood Pressure - drug effects; Body Temperature - drug effects; Cross-Over Studies; Double-Blind Method; Female; Hallucinogens - administration & dosage; Hallucinogens - adverse effects; Healthy Volunteers; Heart Rate - drug effects; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine - administration & dosage; N-Methyl-3,4-methylenedioxyamphetamine - adverse effects; Psychomotor Performance - drug effects; 3,4-methylenedioxymethamphetamine; Phase I; adverse effect; human; safety

3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is being investigated in MDMA-assisted psychotherapy. The present study characterized the safety pharmacology of single-dose administrations of MDMA (75 or 125 mg) using data from nine double-blind, placebo-controlled, crossover studies performed in...