Analyzing pre-post randomized studies with one post-randomization score using repeated measures and ANCOVA models

• Published in: Statistical methods in medical research Vol. 28; no. 10-11; p. 2952
• Main Author: Wan, Fei
• Format: Journal Article
• Language: English
• Published: England 01.11.2019
• Subjects: Acupuncture Therapy; Analysis of Variance; Data Interpretation, Statistical; Headache - therapy; Humans; Randomized Controlled Trials as Topic - statistics & numerical data; Research Design; ANCOVA; marginal treatment effect; conditional treatment effect; Pre-post designs; repeated measures
• ISSN: 1477-0334
• DOI: 10.1177/0962280218789972

The analysis of covariance (ANCOVA) or repeated measures (RM) models are often used to compare the treatment effect between different arms in pre-post randomized studies. ANCOVA adjusts the baseline score as a covariate in regression models. RM treats both the baseline and post-randomization scores...