New insights in gut-liver axis in wild-type murine imiquimod-induced lupus

• Published in: Lupus Vol. 30; no. 6; pp. 926 - 936
• Main Authors: Maalouly, Georges, Hajal, Joelle, Noujeim, Charbel, Choueiry, Michel, Nassereddine, Hussein, Smayra, Viviane, Saliba, Youakim, Fares, Nassim
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.05.2021; Sage Publications Ltd
• Subjects: Antiviral drugs; Digestive system; E coli; Feces; Gastrointestinal tract; Imiquimod; Inflammation; Intestine; Liver; Liver diseases; Lupus; Lupus nephritis; Nephritis; NF-κB protein; Permeability; Proteins; TLR4 protein; TLR7 protein; Toll-like receptors; Zonula occludens-1 protein; Lupus; TLR; gut permeability; mice; calprotectin; imiquimod

Background Intestinal and hepatic manifestations of lupus seem to be underestimated in comparison to other major organ lesions. Although recent data point to gut-liver axis involvement in lupus, gut permeability dysfunction and liver inflammation need to be more investigated. Objective This study ai...