Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation
[Display omitted] Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, sy...
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Published in | International journal of pharmaceutics Vol. 572; p. 118797 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
15.12.2019
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Abstract | [Display omitted]
Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size, hydrophilicity, and morphology, have significant influence on the dynamic granulation process and the final granular product. |
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AbstractList | [Display omitted]
Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size, hydrophilicity, and morphology, have significant influence on the dynamic granulation process and the final granular product. Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size, hydrophilicity, and morphology, have significant influence on the dynamic granulation process and the final granular product. |
ArticleNumber | 118797 |
Author | Li, Chen Zhu, Ning Zhang, Lifeng Emady, Heather N. |
Author_xml | – sequence: 1 givenname: Chen surname: Li fullname: Li, Chen organization: Department of Chemical and Biological Engineering, University of Saskatchewan, Saskatoon, Canada – sequence: 2 givenname: Ning surname: Zhu fullname: Zhu, Ning organization: Department of Chemical and Biological Engineering, University of Saskatchewan, Saskatoon, Canada – sequence: 3 givenname: Heather N. surname: Emady fullname: Emady, Heather N. organization: School for Engineering of Matter, Transport and Energy, Arizona State University, AZ, USA – sequence: 4 givenname: Lifeng surname: Zhang fullname: Zhang, Lifeng email: lifeng.zhang@usask.ca organization: Department of Chemical and Biological Engineering, University of Saskatchewan, Saskatoon, Canada |
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CitedBy_id | crossref_primary_10_1016_j_optlaseng_2024_108329 crossref_primary_10_1016_j_powtec_2020_09_063 crossref_primary_10_1021_acs_molpharmaceut_3c00514 crossref_primary_10_1107_S1600577523000826 crossref_primary_10_1016_j_ijpharm_2020_119660 crossref_primary_10_1002_cjce_24485 crossref_primary_10_1016_j_ijpharm_2022_122192 |
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Keywords | APAP CCS Nucleation Granulation LMH VAR HAR Pharmaceutical powders Synchrotron MCC IBU X-ray imaging |
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Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking... Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short... |
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SubjectTerms | Acetaminophen - chemistry Carboxymethylcellulose Sodium - chemistry Cellulose - chemistry Drug Compounding Excipients - chemistry Granulation Humans Hydrophobic and Hydrophilic Interactions Ibuprofen - chemistry Lactose - chemistry Molecular Imaging Nucleation Particle Size Pharmaceutical powders Powders Synchrotron Synchrotrons Technology, Pharmaceutical - methods X-ray imaging X-Rays |
Title | Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation |
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