Combining multiple biomarkers to linearly maximize the diagnostic accuracy under ordered multi-class setting

• Published in: Statistical methods in medical research Vol. 30; no. 4; p. 1101
• Main Authors: Hua, Jia, Tian, Lili
• Format: Journal Article
• Language: English
• Published: England 01.04.2021
• Subjects: generalized Youden index; biomarker evaluation; multiple classification; ROC analysis; Diagnostic study

Either in clinical study or biomedical research, it is a common practice to combine multiple biomarkers to improve the overall diagnostic performance. Despite the fact there exist a large number of statistical methods for biomarker combination under binary classification, research on this topic unde...