Cytosolic perfluorocarbon delivery to platelets via albumin for antithrombotic therapy

• Published in: Journal of controlled release Vol. 355; pp. 109 - 121
• Main Authors: Luo, Lifeng, Chen, Zhong, Gong, Tong, Ye, Qingsong, Li, Hao, Guo, Yunfei, Wen, Jiqiu, Hu, Yiqiao, Wu, Jinhui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2023
• Subjects: Albumin; Albumins; Antiplatelet; Bleeding; Blood Platelets; Cytosolic delivery; Fibrinolytic Agents - therapeutic use; Humans; Integrins; Perfluorocarbon; Platelet Aggregation; Thrombosis; Thrombosis - drug therapy; Thrombosis - prevention & control; Albumin; Antiplatelet; Thrombosis; Cytosolic delivery; Bleeding; Perfluorocarbon

Thrombosis is a major contributor to global disease burden. Antiplatelet therapy is the critical approach to prevent thrombosis by reducing platelet reactivity. However, classical antiplatelet strategies generally interfere with platelet integrin αIIbβ3-mediated platelet activation, thereby facing s...