Design considerations of aptasensors for continuous monitoring of biomarkers in digestive tract fluids

• Published in: Talanta (Oxford) Vol. 239; p. 123124
• Main Authors: Salama, Rachel, Arshavsky-Graham, Sofia, Sella-Tavor, Osnat, Massad-Ivanir, Naama, Segal, Ester
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2022
• Subjects: Aptamer; Aptamers, Nucleotide; Biomarker; Biomarkers; Biosensing Techniques; Gastrointestinal; Gastrointestinal Tract; Ingestible sensor; Optical biosensor; Porous silicon; Silicon; LOD; GI; Biomarker; EDC; PSi; APTES; EOT; HRSEM; Gastrointestinal; Ingestible sensor; SB; SDS-PAGE; PEG; Aptamer; Porous silicon; Optical biosensor

We present a porous Si (PSi)-based label-free optical biosensor for sensitive and continuous detection of a model target protein biomarker in gastrointestinal (GI) tract fluids. The biosensing platform is designed to continuously monitor its target protein within the complex GI fluids without sample...