N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation

• Published in: Cellular signalling Vol. 69; p. 109553
• Main Authors: Gu, Xiaofei, Zhang, Yiwen, Li, Di, Cai, Hongshi, Cai, Luhui, Xu, Qiong
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2020
• Subjects: FTO; Macrophage polarization; mRNA stability; NF-κB; PPAR-γ; STAT1; FTO; NF-κB; Macrophage polarization; STAT1; PPAR-γ; mRNA stability

Macrophage polarization is the driving force of various inflammatory diseases, especially those involved in M1/M2 imbalance. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in eukaryotes that affects multiple biological processes, including those involved developmental arre...