Supplementation with high-dose cholecalciferol throughout pregnancy induces fetal growth restriction through inhibiting placental proliferation and trophoblast epithelial-mesenchymal transition

• Published in: The Journal of nutritional biochemistry Vol. 91; p. 108601
• Main Authors: Ma, Li, Chen, Yuan-Hua, Liu, Zhi-Bing, Gao, Lan, Wang, Bo, Fu, Lin, Zhang, Shan-Yu, Chen, Wei, Wang, Hua, Xu, De-Xiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2021
• Subjects: Fetal growth restriction; HTR-8/SVneo cell; Placental proliferation; Trophoblast epithelial-mesenchymal transition; Vitamin D3 supplementation; Placental proliferation; HTR-8/SVneo cell; Trophoblast epithelial-mesenchymal transition; Vitamin D3 supplementation; Fetal growth restriction

Vitamin D deficiency has been associated with adverse pregnant outcomes. Several studies investigated the effects of maternal vitamin D3 supplementation on fetal development with inconsistent results. The aim of this study was to investigate the effects of maternal supplementation with different dos...