Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers

• Published in: AIDS research and human retroviruses Vol. 32; no. 3; p. 279
• Main Authors: Rego, Filipe Ferreira de Almeida, de Oliveira, Tulio, Giovanetti, Marta, Galvão-Castro, Bernardo, Gonçalves, Marilda de Souza, Alcantara, Luiz Carlos
• Format: Journal Article
• Language: English
• Published: United States 01.03.2016
• Subjects: Adult; Asymptomatic Infections; Carrier State - virology; Cross-Sectional Studies; Female; Genetic Variation; High-Throughput Nucleotide Sequencing; HTLV-I Infections - pathology; HTLV-I Infections - virology; Human T-lymphotropic virus 1 - classification; Human T-lymphotropic virus 1 - genetics; Human T-lymphotropic virus 1 - isolation & purification; Humans; Male; Middle Aged; Mutation; Polymerase Chain Reaction; Proviruses - genetics; Sequence Analysis, DNA; Terminal Repeat Sequences - genetics; Viral Load; Young Adult

The aim of this study was to analyze patients by deep sequencing the human T cell lymphotropic virus type 1 (HTLV-1) long terminal repeat (LTR) region in order to determine if minor and/or major mutations in this promoter region might be associated with tropical spastic paraparesis (TSP)/human T cel...