The asymptotic maximal procedure for subject randomization in clinical trials

• Published in: Statistical methods in medical research Vol. 27; no. 7; p. 2142
• Main Authors: Zhao, Wenle, Berger, Vance W, Yu, Zhenning
• Format: Journal Article
• Language: English
• Published: England 01.07.2018
• Subjects: subject randomization; Allocation predictability; asymptotic maximal procedure; randomized controlled trial; treatment imbalance

The maximal procedure is a restricted randomization method that maximizes the number of feasible allocation sequences under the constraints of the maximum tolerated imbalance and the allocation sequence length. It assigns an equal probability to all feasible sequences. However, its implementation is...