Analysis of cross-over studies with missing data

• Published in: Statistical methods in medical research Vol. 24; no. 4; pp. 420 - 433
• Main Author: Rosenkranz, Gerd K
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2015; Sage Publications Ltd
• Subjects: Clinical Trials as Topic; Cross-Over Studies; Data Interpretation, Statistical; sensitivity analyses; mixed-effects model; cross-over trials; fixed-effects model; missing data

This paper addresses some aspects of the analysis of cross-over trials with missing or incomplete data. A literature review on the topic reveals that many proposals provide correct results under the missing completely at random assumption while only some consider the more general missing at random s...