Detecting rare haplotypes associated with complex diseases using both population and family data: Combined logistic Bayesian Lasso

• Published in: Statistical methods in medical research Vol. 29; no. 11; p. 3340
• Main Authors: Zhou, Xiaofei, Wang, Meng, Lin, Shili
• Format: Journal Article
• Language: English
• Published: England 01.11.2020
• Subjects: Bayes Theorem; Case-Control Studies; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic; Polymorphism, Single Nucleotide; Association studies; Bayesian Lasso; combined case-control and family data; complex diseases; rare haplotypes

Haplotype-based association methods have been developed to understand the genetic architecture of complex diseases. Compared to single-variant-based methods, haplotype methods are thought to be more biologically relevant, since there are typically multiple non-independent genetic variants involved i...