Reduced delta-6 desaturase activity partially protects against high-fat diet-induced impairment in whole-body glucose tolerance

• Published in: The Journal of nutritional biochemistry Vol. 67; pp. 173 - 181
• Main Authors: Hucik, Barbora, Sarr, Ousseynou, Nakamura, Manabu T., Dyck, David J., Mutch, David M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019
• Subjects: delta-6 Desaturase; Fads2; Fatty acids; Glucose tolerance; High-fat diet; Insulin signaling; Skeletal muscle; Fads2; delta-6 Desaturase; HFD; TLC; LFD; CLAMS; FAT/CD36; AUC; D6D; (LC-) PUFA; PDH; βHAD; GC; HADHSC; WT; AA; FABPpm; AAC; KO; ANSA; ELOVL2; DGLA; IPITT; TBST; DGAT; IPGTT; GS; COX; Fatty acids; Skeletal muscle; Glucose tolerance; DPA; LA; ALA; High-fat diet; EPA; FA; TAG; DHA; PL; RER; Insulin signaling

Delta-6 desaturase (D6D), which is encoded by the fatty acid desaturase (Fads2) gene, is the rate-limiting enzyme for the endogenous production of n-3 long-chain polyunsaturated fatty acids. The absence of D6D activity in Fads2−/− knockout mice results in the inability to produce eicosapentaenoic ac...