An evaluation of microcrystalline cellulose attributes affecting compaction-induced pellet coat damage through a multi-faceted analysis

• Published in: International journal of pharmaceutics Vol. 643; p. 123245
• Main Authors: Thio, Daniel Robin, Aguilera, Quinton, Yeoh, Janice Ke Xin, Sia Heng, Paul Wan, Chan, Lai Wah
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.08.2023
• Subjects: Classification and regression tree algorithm; Compaction pressure; Cushioning effect; Microcrystalline cellulose attributes; Multi-particulates; Pellet coat damage; Cushioning effect; Multi-particulates; Pellet coat damage; Classification and regression tree algorithm; Compaction pressure; Microcrystalline cellulose attributes

[Display omitted] Pellet coat damage in multi-unit pellet system (MUPS) tablets has previously been studied and addressed with limited success. The effects of lactose filler material attributes on pellet coat damage have been relatively well-studied but a similar understanding of microcrystalline ce...