A Meta-Analysis on the Immunogenicity of Homologous versus Heterologous Immunization Regimens against SARS-CoV-2 Beta, Delta, and Omicron BA.1 VoCs in Healthy Adults

• Published in: Journal of microbiology and biotechnology Vol. 35; pp. e2411059 - 17
• Main Authors: Ndzouboukou, Jo-Lewis Banga, Kamara, Abdul A., Ullah, Nadeem, Lei, Qing, Fan, Xiong-lin
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국미생물·생명공학회 24.02.2025
• Subjects: Adult; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 vaccines; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; heterologous booster; homologous booster; Humans; Immunization, Secondary; immunogenicity; Immunogenicity, Vaccine; Neutralization Tests; neutralization titers; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV-2 VoCs; Vaccination - methods; 생물학; COVID-19 vaccines; heterologous booster; homologous booster; immunogenicity; neutralization titers; SARS-CoV-2 VoCs

Since the outbreak of the COVID-19 pandemic, SARS-CoV-2 has not stopped evolving, leading to the emergence of variants of concern (VoCs) involved in significant immune escape. Here, we compared the immunogenicity of different prime-boost vaccination regimens against SARS-CoV-2 wildtype (WT) and its...